Homo sapiens Protein: PPP1R12C
Summary
InnateDB Protein IDBP-70113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R12C
Protein Name protein phosphatase 1, regulatory subunit 12C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263433
InnateDB Gene IDBG-70111 (PPP1R12C)
Protein Structure
UniProt Annotation
Function Regulates myosin phosphatase activity. {ECO:0000269PubMed:11399775}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11399775, ECO:0000269PubMed:12923170}. Note=Along actomyosin filaments and stress fibers. {ECO:0000269PubMed:11399775, ECO:0000269PubMed:12923170}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in heart. {ECO:0000269PubMed:11399775}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR017401 Protein phosphatase 1, regulatory subunit 12A/B/C, eukaryote
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF PIRSF038141
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZL4
PhosphoSite PhosphoSite-Q9BZL4
TrEMBL
UniProt Splice Variant
Entrez Gene 54776
UniGene Hs.631579
RefSeq NP_060077
HUGO HGNC:14947
OMIM 613245
CCDS CCDS12916
HPRD 11452
IMGT
EMBL AB209452 AF211968 AF312028 AK027086 AK129529 AL137618 BC008030
GenPept AAG60045 AAH08030 BAB15651 BAC85179 BAD92689 CAB70844