Version 5.4
Bos taurus Protein: GJA3
Summary
InnateDB Protein IDBP-701132.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJA3
Protein Name Gap junction alpha-3 protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027188
InnateDB Gene IDBG-648376 (GJA3)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity Only detected in the lens.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
Biological Process
GO:0006810 transport
GO:0007154 cell communication
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000500 Connexin
IPR002262 Gap junction alpha-3 protein (Cx46)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PR01133
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P41987
PhosphoSite PhosphoSite-P41987
TrEMBL
UniProt Splice Variant
Entrez Gene 100140301
UniGene Bt.102856
RefSeq NP_001159768
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U08213
GenPept AAA50954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca