InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ARF6

Summary

InnateDB Protein

IDBP-701318.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARF6

Protein Name

ADP-ribosylation factor 6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000056536

InnateDB Gene

IDBG-648584 (ARF6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.

Predicted by orthology
Total	128 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031681	G-protein beta-subunit binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031996	thioesterase binding

Biological Process

GO:0001889	liver development
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0031584	activation of phospholipase D activity
GO:0033028	myeloid cell apoptotic process
GO:0034394	protein localization to cell surface
GO:0035020	regulation of Rac protein signal transduction
GO:0036010	protein localization to endosome
GO:0050432	catecholamine secretion
GO:0051489	regulation of filopodium assembly
GO:0060998	regulation of dendritic spine development
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0090162	establishment of epithelial cell polarity
GO:0097284	hepatocyte apoptotic process

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0031527	filopodium membrane
GO:0042584	chromaffin granule membrane
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00318
PR00449
PR00328

PIRSF

SMART

SM00275
SM00175
SM00178
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt