InnateDB Protein
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IDBP-701463.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SRY
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Protein Name
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Sex-determining region Y protein
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000056194
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InnateDB Gene
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IDBG-648746 (SRY)
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Protein Structure
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Function |
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre- mRNA splicing. Binds to the DNA consensus sequence 5'- [AT]AACAA[AT]-3' (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00267}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009071
High mobility group box domain
IPR017253
Transcription factor SRY
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PFAM |
PF00505
PF09011
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PRINTS |
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PIRSF |
PIRSF037653
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SMART |
SM00398
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TIGRFAMs |
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Modification |
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SwissProt |
Q03255
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q9TSR3
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UniProt Splice Variant |
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Entrez Gene |
280931
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UniGene |
Bt.90486
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RefSeq |
NP_001014407
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB039748
D10843
DQ336526
EU233320
EU294189
EU386186
EU581861
HQ875721
S71489
U15569
Z18808
Z30327
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GenPept |
AAA50602
AAD14086
ABC67486
ABW89571
ABY19364
ABY86906
ACE73647
AEK64473
BAA86975
BAA92368
CAA79272
CAA82981
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