Version 5.4
Bos taurus Protein: FOXA2
Summary
InnateDB Protein IDBP-701474.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXA2
Protein Name forkhead box A2
Synonyms HNF-3b;
Species Bos taurus
Ensembl Protein ENSBTAP00000016463
InnateDB Gene IDBG-648756 (FOXA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0001701 in utero embryonic development
GO:0001705 ectoderm formation
GO:0001708 cell fate specification
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0008344 adult locomotory behavior
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0021533 cell differentiation in hindbrain
GO:0021904 dorsal/ventral neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030193 regulation of blood coagulation
GO:0030324 lung development
GO:0031018 endocrine pancreas development
GO:0032525 somite rostral/caudal axis specification
GO:0033132 negative regulation of glucokinase activity
GO:0040019 positive regulation of embryonic development
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0048468 cell development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048665 neuron fate specification
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448 connective tissue development
GO:0071542 dopaminergic neuron differentiation
GO:0090009 primitive streak formation
GO:2000543 positive regulation of gastrulation
GO:2000971 negative regulation of detection of glucose
GO:2000976 regulation of transcription from RNA polymerase II promoter involved in detection of glucose
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001766 Transcription factor, fork head
IPR013638 Fork-head N-terminal
IPR018533 Forkhead box protein, C-terminal
PFAM PF00250
PF08430
PF09354
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MZB6
UniProt Splice Variant
Entrez Gene 503580
UniGene Bt.20834
RefSeq XP_002692206
HUGO HGNC:5022
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02035840
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca