InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MT-CO2

Summary

InnateDB Protein

IDBP-701828.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MT-CO2

Protein Name

Cytochrome c oxidase subunit 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053151

InnateDB Gene

IDBG-649160 (MT-CO2)

Protein Structure

UniProt Annotation

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0022900	electron transport chain
GO:0055114	oxidation-reduction process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045277	respiratory chain complex IV
GO:0070062	extracellular vesicular exosome
GO:0070469	respiratory chain

Protein Structure and Domains

PDB ID

InterPro

IPR002429 Cytochrome c oxidase subunit II C-terminal
IPR008972 Cupredoxin
IPR011759 Cytochrome C oxidase subunit II, transmembrane domain
IPR014222 Cytochrome c oxidase, subunit II

PFAM

PF00116
PF02790

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-P68530

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB074962 AB074963 AB074964 AB074965 AB074966 AB074967 AB074968 AF490528 AF490529 AF492351 AF493541 AF493542 AY308066 AY308067 AY308068 AY308069 AY526085 AY676855 AY676856 AY676857 AY676858 AY676859 AY676861 AY676862 AY676863 AY676864 AY676865 AY676866 AY676867 AY676868 AY676869 AY676870 AY676871 AY676872 AY676873 DQ124371 DQ124372 DQ124373 DQ124374 DQ124375 DQ124376 DQ124377 DQ124378 DQ124379 DQ124380 DQ124381 DQ124382 DQ124383 DQ124384 DQ124385 DQ124386 DQ124387 DQ124388 DQ124389 DQ124390 DQ124391 DQ124392 DQ124393 DQ124394 DQ124395 DQ124396 DQ124397 DQ124398 DQ124400 DQ124401 DQ124402 DQ124403 DQ124404 DQ124405 DQ124406 DQ124407 DQ124408 DQ124409 DQ124410 DQ124411 DQ124412 DQ124413 DQ124414 DQ124415 DQ124416 DQ124417 DQ124418 DQ347621 DQ347624 DQ347625 EF693802 EU177815 EU177816 EU177817 EU177818 EU177819 EU177820 EU177821 EU177822 EU177823 EU177824 EU177825 EU177826 EU177827 EU177828 EU177829 EU177830 EU177831 EU177832 EU177833 EU177834 EU177835 EU177836 EU177837 EU177838 EU177839 EU177840 EU177841 EU177843 EU177844 EU177845 EU177846 EU177847 EU177848 EU177849 EU177850 EU177851 EU177852 EU177853 EU177854 EU177855 EU177856 EU177858 EU177859 EU177860 EU177861 EU177862 EU177863 EU177864 EU177865 EU177868 EU177869 EU177870 FJ971084 FJ971085 FJ971086 FJ971087 FJ971088 GQ129207 GQ129208 GU947007 GU947008 GU947009 GU947010 GU947011 GU947012 GU947013 GU947014 GU947015 GU947016 GU947017 GU947018 GU947019 GU947020 GU947021 HM045018 HQ025805 HQ184040 HQ184041 HQ184042 HQ184043 HQ184044 HQ184045 JN817300 JN817301 JN817306 JN817307 JN817308 JN817309 JN817310 JN817311 JN817312 JN817313 JN817314 JN817315 JN817316 JN817317 JN817318 JN817319 JN817321 JN817322 JN817323 JN817325 JN817326 JN817328 JN817329 JN817331 JN817332 JN817333 JN817335 JN817336 JN817337 JN817338 JN817339 JN817340 JN817341 JN817342 JN817343 JN817344 JN817345 JN817346 JN817347 JQ967333 KC153972 KC153973 KC153974 KC153975 KC153976 KC153977 KF163072 KF163081 KF163082 KF163083 KF163093 KF926377 M10544 V00654

GenPept

AAA31644 AAM08331 AAM08344 AAM12792 AAM12805 AAP47831 AAP47844 AAP47857 AAP47870 AAQ06596 AAS18245 AAV88113 AAV88126 AAV88139 AAV88152 AAV88165 AAV88191 AAV88204 AAV88217 AAV88230 AAV88243 AAV88256 AAV88269 AAV88282 AAV88295 AAV88308 AAV88321 AAV88334 AAV88347 AAZ16523 AAZ16536 AAZ16549 AAZ16562 AAZ16575 AAZ16588 AAZ16601 AAZ16614 AAZ16627 AAZ16640 AAZ16653 AAZ16666 AAZ16679 AAZ16692 AAZ16705 AAZ16718 AAZ16731 AAZ16744 AAZ16757 AAZ16770 AAZ16783 AAZ16796 AAZ16809 AAZ16822 AAZ16835 AAZ16848 AAZ16861 AAZ16874 AAZ16900 AAZ16913 AAZ16926 AAZ16939 AAZ16952 AAZ16965 AAZ16978 AAZ16991 AAZ17004 AAZ17017 AAZ17030 AAZ17043 AAZ17056 AAZ17069 AAZ17082 AAZ17095 AAZ17108 AAZ17121 AAZ17134 ABC84255 ABC84258 ABC84259 ABV70208 ABV70221 ABV70234 ABV70247 ABV70260 ABV70273 ABV70286 ABV70299 ABV70312 ABV70325 ABV70338 ABV70351 ABV70364 ABV70377 ABV70390 ABV70403 ABV70416 ABV70429 ABV70442 ABV70455 ABV70468 ABV70481 ABV70494 ABV70507 ABV70520 ABV70533 ABV70546 ABV70572 ABV70585 ABV70598 ABV70611 ABV70624 ABV70637 ABV70650 ABV70663 ABV70676 ABV70689 ABV70702 ABV70715 ABV70728 ABV70741 ABV70767 ABV70780 ABV70793 ABV70806 ABV70819 ABV70832 ABV70845 ABV70858 ABV70897 ABV70910 ABV70923 ABW82492 ACQ73804 ACQ73817 ACQ73830 ACQ73843 ACQ73856 ACR19410 ACR19423 ADF29600 ADF49330 ADF49343 ADF49356 ADF49369 ADF49382 ADF49395 ADF49408 ADF49421 ADF49434 ADF49447 ADF49460 ADF49473 ADF49486 ADF49499 ADF49512 ADM35738 ADN11908 ADN11921 ADN11934 ADN11947 ADN11960 ADN11973 AER53677 AER53690 AER53755 AER53768 AER53781 AER53794 AER53807 AER53820 AER53833 AER53846 AER53859 AER53872 AER53885 AER53898 AER53911 AER53924 AER53950 AER53963 AER53976 AER54002 AER54015 AER54041 AER54054 AER54080 AER54093 AER54106 AER54132 AER54145 AER54158 AER54171 AER54184 AER54197 AER54210 AER54223 AER54236 AER54249 AER54262 AER54275 AER54288 AFK75887 AGB56901 AGB56914 AGB56927 AGB56940 AGB56953 AGB56966 AGU00564 AGU00681 AGU00694 AGU00707 AGU00837 AHI51988 BAC54738 BAC54751 BAC54764 BAC54777 BAC54790 BAC54803 BAC54816 CAA24000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca