InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HES1

Summary

InnateDB Protein

IDBP-70187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HES1

Protein Name

hairy and enhancer of split 1, (Drosophila)

Synonyms

bHLHb39; HES-1; HHL; HRY;

Species

Homo sapiens

Ensembl Protein

ENSP00000232424

InnateDB Gene

IDBG-70185 (HES1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269PubMed:18550849}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	49 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0071820	N-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0003143	embryonic heart tube morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003266	regulation of secondary heart field cardioblast proliferation
GO:0003281	ventricular septum development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007219	Notch signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007262	STAT protein import into nucleus
GO:0007389	pattern specification process
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0016477	cell migration
GO:0021537	telencephalon development
GO:0021555	midbrain-hindbrain boundary morphogenesis
GO:0021557	oculomotor nerve development
GO:0021558	trochlear nerve development
GO:0021575	hindbrain morphogenesis
GO:0021861	forebrain radial glial cell differentiation
GO:0021915	neural tube development
GO:0021983	pituitary gland development
GO:0021984	adenohypophysis development
GO:0030324	lung development
GO:0030513	positive regulation of BMP signaling pathway
GO:0030901	midbrain development
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0035019	somatic stem cell maintenance
GO:0035909	aorta morphogenesis
GO:0035910	ascending aorta morphogenesis
GO:0042102	positive regulation of T cell proliferation
GO:0042491	auditory receptor cell differentiation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668	auditory receptor cell fate determination
GO:0043388	positive regulation of DNA binding
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045608	negative regulation of auditory receptor cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045977	positive regulation of mitotic cell cycle, embryonic
GO:0046331	lateral inhibition
GO:0046427	positive regulation of JAK-STAT cascade
GO:0048469	cell maturation
GO:0048505	regulation of timing of cell differentiation
GO:0048538	thymus development
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048844	artery morphogenesis
GO:0050767	regulation of neurogenesis
GO:0060164	regulation of timing of neuron differentiation
GO:0060253	negative regulation of glial cell proliferation
GO:0060412	ventricular septum morphogenesis
GO:0060675	ureteric bud morphogenesis
GO:0060716	labyrinthine layer blood vessel development
GO:0061009	common bile duct development
GO:0061106	negative regulation of stomach neuroendocrine cell differentiation
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626	pharyngeal arch artery morphogenesis
GO:0072012	glomerulus vasculature development
GO:0072049	comma-shaped body morphogenesis
GO:0072050	S-shaped body morphogenesis
GO:0072141	renal interstitial cell development
GO:0072282	metanephric nephron tubule morphogenesis
GO:0090102	cochlea development
GO:0097084	vascular smooth muscle cell development
GO:0097150	neuronal stem cell maintenance
GO:2000227	negative regulation of pancreatic A cell differentiation
GO:2000737	negative regulation of stem cell differentiation
GO:2000974	negative regulation of pro-B cell differentiation
GO:2000978	negative regulation of forebrain neuron differentiation
GO:2000981	negative regulation of inner ear receptor cell differentiation