InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRRC15

Summary

InnateDB Protein

IDBP-70238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRC15

Protein Name

leucine rich repeat containing 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000306276

InnateDB Gene

IDBG-70236 (LRRC15)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0043236	laminin binding

Biological Process

GO:0030335	positive regulation of cell migration
GO:0046813	receptor-mediated virion attachment to host cell
GO:0090005	negative regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TF66

PhosphoSite

PhosphoSite-Q8TF66

TrEMBL

UniProt Splice Variant

Entrez Gene

131578

UniGene

Hs.288467

RefSeq

NP_570843

HUGO

HGNC:20818

OMIM

CCDS

CCDS3306

HPRD

10058

IMGT

EMBL

AB071037 AC125362 AC174158 BC101064 BC101065 BK001325 CH471052

GenPept

AAI01065 AAI01066 BAB84587 DAA01740 EAW78054