Version 5.4
Mus musculus Protein: Galnt1
Summary
InnateDB Protein IDBP-702527.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Galnt1
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000137427
InnateDB Gene IDBG-131485 (Galnt1)
Protein Structure
UniProt Annotation
Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269PubMed:9153242}.
Subcellular Localization Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Polypeptide N- acetylgalactosaminyltransferase 1 soluble form: Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed at high level. Higher expression in kidney, heart, small intestine and cervix and to a lesser extent in all the other tissues tested. {ECO:0000269PubMed:12651884, ECO:0000269PubMed:9153242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006493 protein O-linked glycosylation
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
Cellular Component
GO:0005576 extracellular region
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:894693
InterPro IPR000772 Ricin B lectin domain
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00652
PF14200
PF00535
PRINTS
PIRSF
SMART SM00458
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08912
PhosphoSite PhosphoSite-O08912
TrEMBL E9Q0U0
UniProt Splice Variant
Entrez Gene 14423
UniGene Mm.472096
RefSeq
MGI ID 1XHB
MGI Symbol Galnt1
OMIM
CCDS CCDS29100
HPRD
IMGT
EMBL AC134856 BC056215 BC090962 U73820
GenPept AAB58477 AAH56215 AAH90962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca