InnateDB Protein
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IDBP-702696.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ska1
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Protein Name
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Synonyms
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2810433K01Rik; AV117428;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000137357
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InnateDB Gene
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IDBG-157911 (Ska1)
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Protein Structure
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Function |
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913718
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InterPro |
IPR009829
Protein of unknown function DUF1395
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PFAM |
PF07160
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CPV1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66468
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UniGene |
Mm.436135
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RefSeq |
NP_001157827
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MGI ID |
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MGI Symbol |
Ska1
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OMIM |
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CCDS |
CCDS29341
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HPRD |
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IMGT |
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EMBL |
AK006442
AK013233
AK021226
AK172500
BC019940
DQ926863
DQ926864
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GenPept |
AAH19940
ABJ15826
ABJ15827
BAB24591
BAB28731
BAB32336
BAE43036
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