InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCAT

Summary

InnateDB Protein

IDBP-7031.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCAT

Protein Name

glycine C-acetyltransferase

Synonyms

KBL;

Species

Homo sapiens

Ensembl Protein

ENSP00000248924

InnateDB Gene

IDBG-7029 (GCAT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion {ECO:0000250}. Nucleus {ECO:0000269PubMed:17688197}. Note=Translocates to the nucleus upon cold and osmotic stress.

Disease Associations

Tissue Specificity

Strongly expressed in heart, brain, liver and pancreas. Also found in lung. {ECO:0000269PubMed:10712613}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008890	glycine C-acetyltransferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0019518	L-threonine catabolic process to glycine

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR004839 Aminotransferase, class I/classII
IPR011282 2-amino-3-ketobutyrate coenzyme A ligase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF00155

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75600

PhosphoSite