Version 5.4
Homo sapiens Protein: GPR39
Summary
InnateDB Protein IDBP-70405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR39
Protein Name G protein-coupled receptor 39
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000327417
InnateDB Gene IDBG-70403 (GPR39)
Protein Structure
UniProt Annotation
Function Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in many tissues, including the stomach, intestine and hypothalamus. {ECO:0000269PubMed:9441746}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43194
PhosphoSite PhosphoSite-O43194
TrEMBL Q53RU7
UniProt Splice Variant
Entrez Gene 2863
UniGene Hs.739192
RefSeq NP_001499
HUGO HGNC:4496
OMIM 602886
CCDS CCDS2170
HPRD 04198
IMGT
EMBL AC079773 AC098800 AF034633 AK123759 AK314895 BC125046 BC125047 FJ348258
GenPept AAC26082 AAI25047 AAI25048 AAX93106 AAY24154 ACI96302 BAG37409 BAG53953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca