InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh18a1

Summary

InnateDB Protein

IDBP-704347.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh18a1

Protein Name

Synonyms

2810433K04Rik; AI429789; Pycs;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135426

InnateDB Gene

IDBG-164820 (Aldh18a1)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004349	glutamate 5-kinase activity
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity
GO:0005524	ATP binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006536	glutamate metabolic process
GO:0006561	proline biosynthetic process
GO:0006592	ornithine biosynthetic process
GO:0008152	metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0016310	phosphorylation
GO:0019240	citrulline biosynthetic process
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:1888908

InterPro

IPR000965 Gamma-glutamyl phosphate reductase GPR
IPR001048 Aspartate/glutamate/uridylate kinase
IPR001057 Glutamate/acetylglutamate kinase
IPR005766 Delta l-pyrroline-5-carboxylate synthetase
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF00696
PF00171

PRINTS

PR00474

PIRSF

PIRSF036429

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt