Version 5.4
Homo sapiens Protein: NDUFAF1
Summary
InnateDB Protein IDBP-7044.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFAF1
Protein Name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000260361
InnateDB Gene IDBG-7042 (NDUFAF1)
Protein Structure
UniProt Annotation
Function Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:11935339}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0006461 protein complex assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005747 mitochondrial respiratory chain complex I
Protein Structure and Domains
PDB ID
InterPro IPR008979 Galactose-binding domain-like
IPR013857 NADH:ubiquinone oxidoreductase intermediate-associated protein 30
PFAM PF08547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y375
PhosphoSite PhosphoSite-Q9Y375
TrEMBL H0YNN4
UniProt Splice Variant
Entrez Gene 51103
UniGene Hs.593144
RefSeq NP_057097
HUGO HGNC:18828
OMIM 606934
CCDS CCDS10075
HPRD 09500
IMGT
EMBL AC087721 AF151823 BC000780 CH471125
GenPept AAD34060 AAH00780 EAW92487 EAW92488 EAW92489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca