Version 5.4
Mus musculus Protein: Fbxl15
Summary
InnateDB Protein IDBP-704819.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl15
Protein Name
Synonyms 0710008C12Rik; Fbxo37;
Species Mus musculus
Ensembl Protein ENSMUSP00000137489
InnateDB Gene IDBG-172790 (Fbxl15)
Protein Structure
UniProt Annotation
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart, liver, spleen, bone, muscle, brain and kidney (at protein level). {ECO:0000269PubMed:21572392}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0009953 dorsal/ventral pattern formation
GO:0016567 protein ubiquitination
GO:0030282 bone mineralization
GO:0030513 positive regulation of BMP signaling pathway
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1915681
InterPro IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
SM00367
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91W61
PhosphoSite PhosphoSite-Q91W61
TrEMBL
UniProt Splice Variant
Entrez Gene 68431
UniGene Mm.19973
RefSeq
MGI ID
MGI Symbol Fbxl15
OMIM
CCDS CCDS38007
HPRD
IMGT
EMBL AK003032 AK172339 BC016499 CH466534
GenPept AAH16499 BAE42956 EDL41989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca