Version 5.4
Homo sapiens Protein: XXYLT1
Summary
InnateDB Protein IDBP-70487.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XXYLT1
Protein Name chromosome 3 open reading frame 21
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000309640
InnateDB Gene IDBG-70485 (XXYLT1)
Protein Structure
UniProt Annotation
Function Alpha-1,3-xylosyltransferase, which elongates the O- linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose. {ECO:0000269PubMed:22117070}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:22117070}; Single-pass type II membrane protein {ECO:0000269PubMed:22117070}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016763 transferase activity, transferring pentosyl groups
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002495 Glycosyl transferase, family 8
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF01501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBI6
PhosphoSite PhosphoSite-Q8NBI6
TrEMBL
UniProt Splice Variant
Entrez Gene 152002
UniGene Hs.478741
RefSeq NP_689744
HUGO HGNC:26639
OMIM 614552
CCDS CCDS43188
HPRD 08757
IMGT
EMBL AK057046 AK075551 AK092474 BC019036 BC039067 CH471052
GenPept AAH19036 AAH39067 BAB71355 BAC03899 BAC11694 EAW78028 EAW78029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca