Version 5.4
Mus musculus Protein: Ccdc85b
Summary
InnateDB Protein IDBP-705325.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc85b
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000137537
InnateDB Gene IDBG-702325 (Ccdc85b)
Protein Structure
UniProt Annotation
Function Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion. {ECO:0000269PubMed:15644333}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000269PubMed:15644333}.
Disease Associations
Tissue Specificity Expressed in white and brown adipose tissue. {ECO:0000269PubMed:15644333}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.
Predicted by orthology
Total 120 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID MGI:2147607
InterPro IPR019359 Protein of unknown function DUF2216, coiled-coil
PFAM PF10226
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PDY0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 240514
UniGene
RefSeq NP_941018
MGI ID
MGI Symbol Ccdc85b
OMIM
CCDS CCDS50357
HPRD
IMGT
EMBL BC058411
GenPept AAH58411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca