InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAH17

Summary

InnateDB Protein

IDBP-70771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAH17

Protein Name

dynein, axonemal, heavy chain 17

Synonyms

DNAHL1; DNEL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000374490

InnateDB Gene

IDBG-70765 (DNAH17)

Protein Structure

UniProt Annotation

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:9545504}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0001539	cilium or flagellum-dependent cell motility
GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007165	signal transduction
GO:0008152	metabolic process

Cellular Component

GO:0005858	axonemal dynein complex
GO:0005874	microtubule
GO:0030286	dynein complex

Protein Structure and Domains

PDB ID

InterPro

IPR004273 Dynein heavy chain domain
IPR011072 HR1 rho-binding repeat
IPR011704 ATPase, dynein-related, AAA domain
IPR013594 Dynein heavy chain, domain-1
IPR013602 Dynein heavy chain, domain-2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03028
PF02185
PF07728
PF08385
PF08393

PRINTS

PIRSF

SMART

SM00742

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UFH2