InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX7

Summary

InnateDB Protein

IDBP-7094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX7

Protein Name

SRY (sex determining region Y)-box 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301921

InnateDB Gene

IDBG-7092 (SOX7)

Protein Structure

UniProt Annotation

Function

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'. {ECO:0000250, ECO:0000269PubMed:18819930}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}. Cytoplasm {ECO:0000269PubMed:18819930}.

Disease Associations

Tissue Specificity

Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. {ECO:0000269PubMed:11691915, ECO:0000269PubMed:18819930}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001706	endoderm formation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060828	regulation of canonical Wnt signaling pathway