Version 5.4
Mus musculus Protein: Vipas39
Summary
InnateDB Protein IDBP-710377.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vipas39
Protein Name
Synonyms 6720456H09Rik; 9330175H22Rik; AI413782; hSPE-39; SPE-39; Spe39; Vipar;
Species Mus musculus
Ensembl Protein ENSMUSP00000137190
InnateDB Gene IDBG-160113 (Vipas39)
Protein Structure
UniProt Annotation
Function Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in vesicular trafficking during spermatogenesis (By similarity). May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin. {ECO:0000250, ECO:0000269PubMed:20190753}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Late endosome {ECO:0000250}. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006886 intracellular protein transport
GO:0007283 spermatogenesis
GO:0008333 endosome to lysosome transport
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030897 HOPS complex
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID MGI:2144805
InterPro IPR019177 Golgin subfamily A member 5
PFAM PF09787
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGQ1
PhosphoSite PhosphoSite-Q8BGQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 104799
UniGene Mm.208750
RefSeq NP_001136053
MGI ID
MGI Symbol Vipas39
OMIM
CCDS CCDS26074
HPRD
IMGT
EMBL AK046322 AK049643 AK079055 AK082261 BC016646 BC023716
GenPept AAH16646 AAH23716 BAC32680 BAC33854 BAC37516 BAC38449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca