Version 5.4
Mus musculus Protein: Ttll5
Summary
InnateDB Protein IDBP-710868.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttll5
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134971
InnateDB Gene IDBG-158796 (Ttll5)
Protein Structure
UniProt Annotation
Function Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. {ECO:0000269PubMed:17499049}.
Subcellular Localization Cell projection, cilium {ECO:0000269PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:17499049}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In ciliated cells, located in both cilia and basal bodies. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain, kidney, liver, spleen and testis. {ECO:0000269PubMed:17499049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016874 ligase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006464 cellular protein modification process
GO:0007283 spermatogenesis
GO:0007288 sperm axoneme assembly
GO:0009566 fertilization
GO:0018095 protein polyglutamylation
GO:0030317 sperm motility
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:2443657
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CHB8
PhosphoSite PhosphoSite-Q8CHB8
TrEMBL H3BJC2
UniProt Splice Variant
Entrez Gene 320244
UniGene Mm.487639
RefSeq
MGI ID
MGI Symbol Ttll5
OMIM
CCDS
HPRD
IMGT
EMBL AB093278 AC134328 AC138303 AK006726 AK009255 AK028083 AM690748 BC035276
GenPept AAH35276 BAB24715 BAC25741 BAC41462 BAE43213 CAM84325

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca