Version 5.4
| Mus musculus Protein: Dpf3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-710892.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Dpf3 | ||||||||
| Protein Name | |||||||||
| Synonyms | 2810403B03Rik; 6530402L11Rik; BAF45C; C78788; cer-d4; CERD4; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000136280 | ||||||||
| InnateDB Gene | IDBG-155150 (Dpf3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:17640523}. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in the heart and somites. Expressed in cerebellum and spinal cord, but not in cerebral cortex. Expressed specifically in post-mitotic neurons (at protein level). {ECO:0000269PubMed:17640523, ECO:0000269PubMed:18765789, ECO:0000269PubMed:8812431}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1917377 | ||||||||
| InterPro |
IPR001965
Zinc finger, PHD-type IPR007087 Zinc finger, C2H2 IPR011011 Zinc finger, FYVE/PHD-type IPR015880 Zinc finger, C2H2-like IPR019787 Zinc finger, PHD-finger |
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| PFAM |
PF00096
PF00628 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00249
SM00355 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P58269 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 70127 | ||||||||
| UniGene | Mm.151308 | ||||||||
| RefSeq | NP_001254554 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Dpf3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS59574 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF362750 AK039011 BC048572 | ||||||||
| GenPept | AAH48572 AAK54538 BAC30204 | ||||||||