InnateDB Protein
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IDBP-71091.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC51A
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Protein Name
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Organic solute transporter subunit alpha
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000296327
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InnateDB Gene
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IDBG-71089 (SLC51A)
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Protein Structure
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Function |
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. {ECO:0000269PubMed:16317684}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005178
Organic solute transporter subunit alpha/Transmembrane protein 184
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PFAM |
PF03619
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86UW1
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PhosphoSite |
PhosphoSite-Q86UW1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
200931
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UniGene |
Hs.722938
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RefSeq |
NP_689885
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HUGO |
HGNC:29955
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OMIM |
612084
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CCDS |
CCDS3314
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HPRD |
17810
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IMGT |
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EMBL |
AK172837
AY194243
CH471191
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GenPept |
AAP23993
BAD18802
EAW53665
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