InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 1110021L09Rik

Summary

InnateDB Protein

IDBP-711637.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

1110021L09Rik

Protein Name

Synonyms

1110021L09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137431

InnateDB Gene

IDBG-137976 (1110021L09Rik)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in the lung, pancreas and kidney. High expression in the CNS, particularly in the hypothalamus, the thalamus and the cerebellum. In the forebrain, abundantly expressed in the telencephalon, especially in the cerebral cortex layers, except layer 1, as well as in the induseum griseum, the piriform area, the taenia tecta, dorsal part and in the entorhinal area, lateral part. Lower levels in the bed anterior olfactory nucleus, posteroventral part and in layer two of the olfactory tubercle. In the amygdala, high levels observed in the intercalated nucleus and the medial nucleus. In the diencephalon, expressed in the nuclei in both the hypothalamus and thalamus. Among the hypothalamic areas, strongest expression in the arcuate nucleus and in the ventromedial nucleus, as well as in the suprachiasmatic nucleus, anterior nucleus, especially in its central part, and in the magnocellular division of the paraventricular nucleus. In the thalamus, highest levels in the medial habenula. Expression also observed in the paraventricular thalamic nucleus, parataenial nucleus, central medial nucleus, intermediodorsal nucleus and lateral dorsal nucleus. In the hindbrain, detected in the cerebellum and in the pons. In the midbrain and the medulla, expression levels were modest. In the midbrain, highest expression in the periaqueductal gray and all subdivisions of the interpeduncular nucleus, except for the caudal part. In the pons, the strongest labeling was seen in the nucleus incertus and in the tegmental nucleus. {ECO:0000269PubMed:19697161}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006810	transport
GO:0008150	biological_process
GO:0055085	transmembrane transport

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1923556

InterPro

IPR000576 LacY/RafB permease family
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF01306
PF07690

PRINTS

PR00174

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

D3Z5L6