InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENPP7

Summary

InnateDB Protein

IDBP-71172.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP7

Protein Name

ectonucleotide pyrophosphatase/phosphodiesterase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000332656

InnateDB Gene

IDBG-71170 (ENPP7)

Protein Structure

UniProt Annotation

Function

Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269PubMed:12885774}.

Subcellular Localization

Membrane {ECO:0000269PubMed:12671034, ECO:0000305}; Single-pass type I membrane protein {ECO:0000269PubMed:12671034, ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000269PubMed:12671034, ECO:0000269PubMed:12885774}.

Disease Associations

Tissue Specificity

Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. {ECO:0000269PubMed:12671034, ECO:0000269PubMed:12885774}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006684	sphingomyelin metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0008152	metabolic process
GO:0008156	negative regulation of DNA replication
GO:0008285	negative regulation of cell proliferation
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR006124 Metalloenzyme
IPR017850 Alkaline-phosphatase-like, core domain

PFAM

PF01663
PF01676

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6UWV6

PhosphoSite