InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPOPL

Summary

InnateDB Protein

IDBP-71175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPOPL

Protein Name

speckle-type POZ protein-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000280098

InnateDB Gene

IDBG-71173 (SPOPL)

Protein Structure

UniProt Annotation

Function

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. {ECO:0000269PubMed:22632832}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031397	negative regulation of protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process