InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBX8

Summary

InnateDB Protein

IDBP-71218.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBX8

Protein Name

chromobox homolog 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000269385

InnateDB Gene

IDBG-71216 (CBX8)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:21282530}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21282530}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	116 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003727	single-stranded RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0035064	methylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016574	histone ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex