InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSGALNACT2

Summary

InnateDB Protein

IDBP-71221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSGALNACT2

Protein Name

chondroitin sulfate N-acetylgalactosaminyltransferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363590

InnateDB Gene

IDBG-71219 (CSGALNACT2)

Protein Structure

UniProt Annotation

Function

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. {ECO:0000269PubMed:12433924, ECO:0000269PubMed:12446672}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12433924, ECO:0000269PubMed:12446672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008376	acetylgalactosaminyltransferase activity
GO:0046872	metal ion binding
GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0030166	proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
GO:0050651	dermatan sulfate proteoglycan biosynthetic process
GO:0050652	dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0050653	chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process