InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFS1

Summary

InnateDB Protein

IDBP-71240.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFS1

Protein Name

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

Synonyms

IscS; NIFS;

Species

Homo sapiens

Ensembl Protein

ENSP00000363198

InnateDB Gene

IDBG-402145 (NFS1)

Protein Structure

UniProt Annotation

Function

Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. {ECO:0000269PubMed:18650437}.

Subcellular Localization

Isoform Mitochondrial: Mitochondrion.Isoform Cytoplasmic: Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0031071	cysteine desulfurase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006461	protein complex assembly
GO:0006520	cellular amino acid metabolic process
GO:0006534	cysteine metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006777	Mo-molybdopterin cofactor biosynthetic process
GO:0008152	metabolic process
GO:0018283	iron incorporation into metallo-sulfur cluster
GO:0032324	molybdopterin cofactor biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase
IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR010240 Cysteine desulfurase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR016454 Cysteine desulfurase, NifS

PFAM

PF00266
PF01041
PF01212

PRINTS

PIRSF

PIRSF000390
PIRSF005572

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y697