InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO45

Summary

InnateDB Protein

IDBP-71253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO45

Protein Name

F-box protein 45

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310332

InnateDB Gene

IDBG-71251 (FBXO45)

Protein Structure

UniProt Annotation

Function

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. {ECO:0000250, ECO:0000269PubMed:19581926}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0006974	cellular response to DNA damage stimulus
GO:0007399	nervous system development
GO:0016567	protein ubiquitination
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021800	cerebral cortex tangential migration
GO:0021957	corticospinal tract morphogenesis
GO:0021960	anterior commissure morphogenesis
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0060384	innervation
GO:0060386	synapse assembly involved in innervation