InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hectd1

Summary

InnateDB Protein

IDBP-712641.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hectd1

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136449

InnateDB Gene

IDBG-138340 (Hectd1)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in development of the head mesenchyme and neural tube closure. {ECO:0000269PubMed:17442300}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001843	neural tube closure
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2384768

InterPro

IPR000569 HECT
IPR002110 Ankyrin repeat
IPR008979 Galactose-binding domain-like
IPR010606 Mib-herc2
IPR012919 Sad1/UNC-like, C-terminal
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM