InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRP5

Summary

InnateDB Protein

IDBP-71287.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP5

Protein Name

NLR family, pyrin domain containing 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375063

InnateDB Gene

IDBG-71285 (NLRP5)

Protein Structure

UniProt Annotation

Function

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Oocyte-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007566	embryo implantation
GO:0009566	fertilization
GO:0009887	organ morphogenesis
GO:0031647	regulation of protein stability
GO:0034613	cellular protein localization
GO:0043487	regulation of RNA stability
GO:0043623	cellular protein complex assembly
GO:0045087	innate immune response (InnateDB)
GO:0070997	neuron death

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0043234	protein complex
GO:0045179	apical cortex

Protein Structure and Domains

PDB ID

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P59047