InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFV2

Summary

InnateDB Protein

IDBP-713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFV2

Protein Name

NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa

Synonyms

CI-24k;

Species

Homo sapiens

Ensembl Protein

ENSP00000327268

InnateDB Gene

IDBG-711 (NDUFV2)

Protein Structure

UniProt Annotation

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0007399	nervous system development
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0048738	cardiac muscle tissue development
GO:0055114	oxidation-reduction process