InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Micu1

Summary

InnateDB Protein

IDBP-713232.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Micu1

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136567

InnateDB Gene

IDBG-154021 (Micu1)

Protein Structure

UniProt Annotation

Function

Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. {ECO:0000269PubMed:24560927}.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Localizes at the outer surface of the mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, heart, kidney, liver, brain, lung, fat and spleen. {ECO:0000269PubMed:21685888, ECO:0000269PubMed:23409044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006851	mitochondrial calcium ion transport
GO:0051560	mitochondrial calcium ion homeostasis
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0070509	calcium ion import

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0032592	integral component of mitochondrial membrane
GO:0034704	calcium channel complex
GO:1990246	uniplex complex