InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad17

Summary

InnateDB Protein

IDBP-713363.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad17

Protein Name

Synonyms

MmRad24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136292

InnateDB Gene

IDBG-178216 (Rad17)

Protein Structure

UniProt Annotation

Function

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity). Essential for embryonic development. May be involved in homologous recombination. {ECO:0000250, ECO:0000269PubMed:15297881}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous at low levels. Highly expressed in testis, where it is expressed in spermatogonia, spermatocytes and spermatids, but absent in mature spermatozoa (at protein level). {ECO:0000269PubMed:10232579, ECO:0000269PubMed:10480350, ECO:0000269PubMed:9933569}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007093	mitotic cell cycle checkpoint
GO:0007275	multicellular organismal development
GO:0008156	negative regulation of DNA replication
GO:0042325	regulation of phosphorylation

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1333807

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR018324 Checkpoint protein Rad24, fungi/metazoa
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6NXW6