Version 5.4
Homo sapiens Protein: ROMO1
Summary
InnateDB Protein IDBP-71363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROMO1
Protein Name reactive oxygen species modulator 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338293
InnateDB Gene IDBG-71355 (ROMO1)
Protein Structure
UniProt Annotation
Function Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:16842742, ECO:0000269PubMed:19535734}; Single-pass membrane protein {ECO:0000269PubMed:16842742, ECO:0000269PubMed:19535734}.
Disease Associations
Tissue Specificity Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors. {ECO:0000269PubMed:16842742, ECO:0000269PubMed:19535734}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001302 replicative cell aging
GO:0008284 positive regulation of cell proliferation
GO:0034614 cellular response to reactive oxygen species
GO:0042742 defense response to bacterium
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018450 Reactive oxygen species modulator 1
PFAM PF10247
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P60602
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 140823
UniGene
RefSeq
HUGO HGNC:16185
OMIM
CCDS CCDS13264
HPRD 12774
IMGT
EMBL AL357374 AM397244 AM397245 AM397246 BC008488 BC105281 CH471077 GU727625
GenPept AAH08488 AAI05282 ADU87627 CAC11117 CAI13604 CAL37002 CAL37003 CAL37004 EAW76168 EAW76169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca