InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALP

Summary

InnateDB Protein

IDBP-71371.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALP

Protein Name

galanin-like peptide

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349884

InnateDB Gene

IDBG-71369 (GALP)

Protein Structure

UniProt Annotation

Function

Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644). {ECO:0000269PubMed:23537644}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0007218	neuropeptide signaling pathway
GO:0008150	biological_process
GO:0009725	response to hormone
GO:0032098	regulation of appetite
GO:0032868	response to insulin
GO:0042595	behavioral response to starvation