InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sulf1

Summary

InnateDB Protein

IDBP-713845.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sulf1

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136014

InnateDB Gene

IDBG-133719 (Sulf1)

Protein Structure

UniProt Annotation

Function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004065	arylsulfatase activity
GO:0005509	calcium ion binding
GO:0008449	N-acetylglucosamine-6-sulfatase activity
GO:0008484	sulfuric ester hydrolase activity

Biological Process

GO:0001502	cartilage condensation
GO:0001822	kidney development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0002063	chondrocyte development
GO:0003094	glomerular filtration
GO:0006790	sulfur compound metabolic process
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014846	esophagus smooth muscle contraction
GO:0016525	negative regulation of angiogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030201	heparan sulfate proteoglycan metabolic process
GO:0030336	negative regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0032836	glomerular basement membrane development
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway
GO:0036022	limb joint morphogenesis
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048706	embryonic skeletal system development
GO:0051216	cartilage development
GO:0060348	bone development
GO:0060384	innervation
GO:0060686	negative regulation of prostatic bud formation

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:2138563

InterPro

IPR000917 Sulfatase
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR014615 Extracellular sulfatase
IPR017850 Alkaline-phosphatase-like, core domain
IPR024609 Extracellular sulfatase, C-terminal

PFAM

PF00884
PF01663
PF12548

PRINTS

PIRSF

PIRSF036665

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K007