InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL18

Summary

InnateDB Protein

IDBP-71392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL18

Protein Name

interleukin 18 (interferon-gamma-inducing factor)

Synonyms

IGIF; IL-18; IL-1g; IL1F4;

Species

Homo sapiens

Ensembl Protein

ENSP00000280357

InnateDB Gene

IDBG-71390 (IL18)

Protein Structure

UniProt Annotation

Function

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0010628	positive regulation of gene expression
GO:0030101	natural killer cell activation
GO:0030155	regulation of cell adhesion
GO:0030431	sleep
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0034105	positive regulation of tissue remodeling
GO:0042033	chemokine biosynthetic process
GO:0042088	T-helper 1 type immune response
GO:0042092	type 2 immune response
GO:0042094	interleukin-2 biosynthetic process
GO:0042095	interferon-gamma biosynthetic process
GO:0042104	positive regulation of activated T cell proliferation
GO:0042231	interleukin-13 biosynthetic process
GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0051142	positive regulation of NK T cell proliferation
GO:0071407	cellular response to organic cyclic compound