InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbc1d7

Summary

InnateDB Protein

IDBP-714567.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbc1d7

Protein Name

Synonyms

2610009C09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137280

InnateDB Gene

IDBG-147276 (Tbc1d7)

Protein Structure

UniProt Annotation

Function

Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question. {ECO:0000269PubMed:22795129}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000250}. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0031398	positive regulation of protein ubiquitination
GO:0032007	negative regulation of TOR signaling
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0070848	response to growth factor