InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxj2

Summary

InnateDB Protein

IDBP-714703.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxj2

Protein Name

Synonyms

Fhx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137645

InnateDB Gene

IDBG-185841 (Foxj2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Able to bind to two different type of DNA binding sites. {ECO:0000269PubMed:11025217}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

In embryos, both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM) show expression. Expressed in adult brain, heart skeletal muscle, lung, kidney and gonads. Liver, small intestine, and spleen also show expression but at lower levels. In the testis, expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, also expressed in Sertoli cells of the testis. In the ovary, only granulosa cells of the follicles show expression. In the brain, expressed in the piriform cortex, hippocampus, habenula and in the granula cell layer in the cerebellum. {ECO:0000269PubMed:11025217, ECO:0000269PubMed:16376864}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0009888	tissue development
GO:0045893	positive regulation of transcription, DNA-templated