InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irx4

Summary

InnateDB Protein

IDBP-715202.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irx4

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134738

InnateDB Gene

IDBG-165490 (Irx4)

Protein Structure

UniProt Annotation

Function

Likely to be an important mediator of ventricular differentiation during cardiac development.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the developing central nervous system, skin, and vibrissae, but predominantly expressed in the cardiac ventricles of the developing heart. Not expressed in the developing metanephric kidney or adult kidney. {ECO:0000269PubMed:10625552, ECO:0000269PubMed:10926765}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0030154	cell differentiation
GO:0048561	establishment of organ orientation