Version 5.4
Homo sapiens Protein: C11orf34
Summary
InnateDB Protein IDBP-71565.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C11orf34
Protein Name chromosome 11 open reading frame 34
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000341412
InnateDB Gene IDBG-71563 (C11orf34)
Protein Structure
UniProt Annotation
Function Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000250}; Lipid- anchor, GPI-anchor {ECO:0000250}. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001953 negative regulation of cell-matrix adhesion
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0035313 wound healing, spreading of epidermal cells
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UQ28
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 349633
UniGene Hs.632097
RefSeq NP_001138496
HUGO HGNC:30053
OMIM 611904
CCDS
HPRD
IMGT
EMBL AP002884 AY364431 AY364432 AY364434 AY364435
GenPept AAQ72434 AAQ72435 AAQ72437 AAQ72438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca