InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dynlt1b

Summary

InnateDB Protein

IDBP-715671.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dynlt1b

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137171

InnateDB Gene

IDBG-703416 (Dynlt1b)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility. {ECO:0000250}.Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor- independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to mitotic spindles. {ECO:0000250}.

Disease Associations

Tissue Specificity

High level in testis (germ cell-specific). Expressed in sperm (at protein level). 200-fold lower in liver, brain, heart, spleen, and kidney. Levels in thymus and two embryonal carcinoma cell lines were several-fold higher than this low constitutive level. {ECO:0000269PubMed:9490726}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0006810	transport
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0050768	negative regulation of neurogenesis

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule

Protein Structure and Domains

PDB ID

MGI:98643

InterPro

IPR005334 Tctex-1

PFAM

PF03645

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51807

PhosphoSite

PhosphoSite-P51807

TrEMBL

UniProt Splice Variant

Entrez Gene

21648

UniGene

RefSeq

NP_033368

MGI ID

MGI Symbol

Dynlt1b

OMIM

CCDS

CCDS49936

HPRD

IMGT

EMBL

AK133788 AK153971 AK168478 BC043018 BC087868 M25825

GenPept

AAA40408 AAH43018 AAH87868 BAE21842 BAE32288 BAE40367