Version 5.4
Mus musculus Protein: Tdrd5
Summary
InnateDB Protein IDBP-715818.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tdrd5
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000137298
InnateDB Gene IDBG-200203 (Tdrd5)
Protein Structure
UniProt Annotation
Function Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. {ECO:0000269PubMed:21383078}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21383078}. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.
Disease Associations
Tissue Specificity Gonad-specific. Mainly expressed in testis. Present at low level in ovary (at protein level). {ECO:0000269PubMed:15465492, ECO:0000269PubMed:21383078}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007286 spermatid development
GO:0030719 P granule organization
GO:0043046 DNA methylation involved in gamete generation
Cellular Component
GO:0033391 chromatoid body
GO:0071546 pi-body
Protein Structure and Domains
PDB ID MGI:2684949
InterPro IPR002999 Tudor domain
PFAM PF00567
PRINTS
PIRSF
SMART SM00333
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VCS6
PhosphoSite PhosphoSite-Q5VCS6
TrEMBL
UniProt Splice Variant
Entrez Gene 214575
UniGene Mm.454129
RefSeq NP_001128213
MGI ID
MGI Symbol Tdrd5
OMIM
CCDS CCDS56647
HPRD
IMGT
EMBL AC161414 AK132674 AK133026 AY522557 BC099972
GenPept AAH99972 AAU04873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca