InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCAM1

Summary

InnateDB Protein

IDBP-71586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCAM1

Protein Name

neural cell adhesion molecule 1

Synonyms

CD56; MSK39; NCAM;

Species

Homo sapiens

Ensembl Protein

ENSP00000318472

InnateDB Gene

IDBG-71584 (NCAM1)

Protein Structure

UniProt Annotation

Function

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cell membrane; Single-pass type I membrane protein.Isoform 3: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 4: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.Isoform 5: Secreted.Isoform 6: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0019221	cytokine-mediated signaling pathway
GO:0030198	extracellular matrix organization
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR009138 Neural cell adhesion
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PR01838

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt