InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: FOXL1

Summary

InnateDB Protein

IDBP-715894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXL1

Protein Name

Synonyms

fkh-6; Fkh6; FREAC7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137732

InnateDB Gene

IDBG-704766 (FOXL1)

Protein Structure

UniProt Annotation

Function

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors. {ECO:0000269PubMed:19049965, ECO:0000269PubMed:9203584}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007495	visceral mesoderm-endoderm interaction involved in midgut development
GO:0007507	heart development
GO:0030111	regulation of Wnt signaling pathway
GO:0030166	proteoglycan biosynthetic process
GO:0061146	Peyer's patch morphogenesis