Mus musculus Protein: Ear1
Summary
InnateDB Protein IDBP-716087.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ear1
Protein Name
Synonyms EAR-1; ECP 1; Raf1;
Species Mus musculus
Ensembl Protein ENSMUSP00000136385
InnateDB Gene IDBG-152425 (Ear1)
Protein Structure
UniProt Annotation
Function Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic granule {ECO:0000250}. Note=Matrix of eosinophil's large specific granule. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0008150 biological_process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:108021
InterPro IPR001427 Ribonuclease A
IPR023412 Ribonuclease A-domain
PFAM PF00074
PRINTS PR00794
PIRSF
SMART SM00092
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97426
PhosphoSite PhosphoSite-
TrEMBL Q53ZF0
UniProt Splice Variant
Entrez Gene 13586
UniGene Mm.86948
RefSeq
MGI ID
MGI Symbol Ear1
OMIM
CCDS CCDS26964
HPRD
IMGT
EMBL AF408692 AY316149 BC117060 HG328945 U72032
GenPept AAB37786 AAI17061 AAL60158 AAP82021 CDG32021