InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsd3b4

Summary

InnateDB Protein

IDBP-716132.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd3b4

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136588

InnateDB Gene

IDBG-707027 (Hsd3b4)

Protein Structure

UniProt Annotation

Function

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD IV can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Does not function as a isomerase.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Kidney; found only in the cortex, appears to be associated with the proximal tubules; and a minor expression in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662	coenzyme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0035634	response to stilbenoid
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:96236

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR008030 NmrA-like
IPR013120 Male sterility, NAD-binding
IPR013968 Polyketide synthase, KR

PFAM