Version 5.4
Mus musculus Protein: Kcnb2
Summary
InnateDB Protein IDBP-716233.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnb2
Protein Name
Synonyms 9630047L19Rik; BB130875; Kv2.2;
Species Mus musculus
Ensembl Protein ENSMUSP00000135382
InnateDB Gene IDBG-606523 (Kcnb2)
Protein Structure
UniProt Annotation
Function Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:99632
InterPro IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003970 Potassium channel, voltage dependent, Kv8.1
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003973 Potassium channel, voltage dependent, Kv2
IPR003974 Potassium channel, voltage dependent, Kv3
IPR005821 Ion transport domain
IPR005826 Potassium channel, voltage dependent, Kv2.2
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
PFAM PF02214
PF03521
PF00520
PF07885
PRINTS PR00169
PR01491
PR01492
PR01493
PR01494
PR01495
PR01498
PR01515
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H8H5
PhosphoSite PhosphoSite-A6H8H5
TrEMBL
UniProt Splice Variant
Entrez Gene 98741
UniGene Mm.156081
RefSeq
MGI ID
MGI Symbol Kcnb2
OMIM
CCDS CCDS48222
HPRD
IMGT
EMBL AC126049 AC132603 AC137555 AC166075 BC146609
GenPept AAI46610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca